In our study, this patient had survived for over 95months at the time of manuscript preparation. 2004;103:27582. Most DLBCL cases of the tongue base had no Bcl-2, Bcl-6, or c-Myc rearrangement and they were sensitive to rituximab. XS and QL did the HPV ISH. The aetiological factors for lymphoma of the oral region other than EBV and HIV are little known. Reference Sands and Tewfik 1 The aetiology is poorly understood, . Generally, MCL patients have a median age of 60years and a striking male predominance [42] .Three of the four cases of MCL including our case, occurred at the base of the tongue. Histologically, there was a monomorphous population of intermediate- to large-sized lymphocytes with slightly irregular indented nuclei and moderately dispersed chromatin (Fig. The follow-up period started from the date of diagnosis until August 30, 2019, and ranged from 3 to 90months. Before All DLBCL cases were positive for CD20, Mum1,Bcl-2 and Bcl-6 and negative for CD5. PMC All cases were negative for EBV ISH but one case was positive for HPV DNA ISH while the other six cases were negative for HPV DNA ISH. California Privacy Statement, https://doi.org/10.1053/ajot.2000.8382. At the time of manuscript preparation, there were only four articles indexed in Medline that described PTCL and tongue involvement (Table 4, [12,13,14,15]). Chemotherapy containing rituximab was considered to significantly improve survival in DLBCL and MCL patients [39, 43]. AJR Am J Roentgenol. MCLs in the tongue base are even rarer. Sirsath NT, Lakshmaiah KC, Das U, Lokanatha D, Chennagiri SP, Ramarao C. Primary extranodal non-Hodgkin's lymphoma of oral cavity--a single Centre retrospective study. c. Immunohistochemistry staining showed diffuse and strong staining of P16 protein (40 x) d. Immunohistochemistry staining showed diffuse and strong staining of P16 protein (100 x). Follicular lymphoid hyperplasia (FLH) is a benign lymphoproliferative process of unknown etiology, uncommon in the head and neck region. Lymphoma is the second most common primary malignancy occurring in the head and neck behind squamous cell carcinoma, while NHL accounts for 6590% of all lymphomas occurring in the head and neck [1, 2] .2030% of NHLs are derived from extra-nodal sites [3] .Nonetheless, NHL with a primary site in the oral cavity is rare, and in the tongue base, even rarer [4, 5]. Immunohistochemistry was negative for lymphoma. Kaohsiung J Med Sci. MeSH Seven cases were identified from the Pathological Registry Database at Peking Union Medical College Hospital (PUMCH). Asano N, Suzuki R, Kagami Y, Ishida F, Kitamura K, Fukutani H, Morishima Y, Takeuchi K, Nakamura S. Clinicopathologic and prognostic significance of cytotoxic molecule expression in nodal peripheral T-cell lymphoma, unspecified. https://doi.org/10.1309/YHFE-R65B-D3LK-3GGV. Google Scholar. Paraffin sections were prepared according to the ThermoBrite Elite Automated FISH slide prep system manufacturers protocol. 1987;149:57581. 3). Acta Oncol. There was no cervical adenopathy, and CT of the thorax and abdomen was negative. In addition, an understanding of these diseases will allow the development of new targeted therapies for these aggressive lymphomas. One of the DLBCL cases was positive for HPV DNA and diffusely expressed P16 protein. Three out of four cases had a high Ki-67 index. The most common symptoms are varying degrees of discomfort in the pharynx, such as the sensation of a foreign body or choking while drinking. Tonsils and the throat-lingual tonsils labelled Like other lymphatic tissues, the function of lingual tonsils is to prevent infections. 96, no. It tends to present as a unilateral, painless, slow-growing, nonulcerated mass. In the study of Eisuke et al., hypermethylation of the p16 promotor indicated a poor prognosis [35]. The number of cases in the present study was low, so further studies will be needed to better understand the relationship between HPV infection and lymphoma of the base of the tongue. During the follow up period, the MCL patient and an elderly DLBCL patient died. These cells are designed to fight. HPV is considered to be associated with the occurrence of oropharyngeal squamous cell carcinoma [8], therefore, we detected the infection status of the the two viruses in lymphoma of the base of the tongue. Two probes (EBV and HPV) were used for all seven cases. For these, please consult a doctor (virtually or in person). 2010;77:96105. Head Neck. What are the symptoms and prognosis for a benign reactive lymphoid hyperplasia of the neck lymph node? Lee YY, Van Tassel P, Nauert C, North LB, Jing BS. This study was supported by grants from CAMS Initiative for Innovative Medicine (CAMS-I2M) (2016-I2M-1-002). Am J Hematol. We thank Violette Ghali, Gina Elhammady, Mark Persky and Songyang Yuan for confirming the pathological diagnosis. Similarly, the inner cortex has T cells and is called the T-cell zone. Video chat with a U.S. board-certified doctor 24/7 in a minute. Please note, we cannot prescribe controlled substances, diet pills, antipsychotics, or other commonly abused medications. Only one widely disseminated case has been referenced, which involved cervical nodes, major salivary glands, orbits, and mediastinum [4]. ENT manifestations of gastroesophageal reflux. Oral and Maxillofacial Pathology. These results all indicate that HPV positivity does not have much impact on the overall survival of DLBCL patients. Had biopsy on axillary lymph node. She is founder and cohost of the International Oral Lichen Planus Support Group (dentistry.tamhsc.edu/olp) and coauthor of General and Oral Pathology for the Dental Hygienist, now in its third edition. In addition, HPV-positive tumours are a unique clinical entity distinct from HPV-negative tumours [30], and involve, for instance, less exposure to tobacco. Cancer at the base of the tongue is usually diagnosed at an advanced stage, when the tumor is larger and the cancer has spread into the lymph nodes in the neck. 2008;100:2619. As always, continue to ask good questions and listen to what your patients are telling you! While an association with bacterial infection has not been clearly identified, one aggressive case of FLH has been linked to the presence of Epstein-Barr virus, causing clonal arrangement (expansion) in the local tissue DNA [4]. A case of benign lymphoid hyperplasia (BLH) of the tongue is reported. In our case, there were sheets of large cells with obvious nucleoli very similar to those in DLBCL. Severe benign lymphoid hyperplasia (LH) is unusual in the head and neck region, but the diagnosis of LH is of clinical importance as it may be confused with malignant lymphoma, both on clinical examination and pathologically. Case report: A 53-year-old female presented with globus sensation, mild dysphagia, nocturnal breathing problems and 'hot potato voice' dysphonia. Cyclophosphamide, doxorubicin, vincristine, prednisone, Peripheral T cell lymphoma, not otherwise specified. Saxman S, Righi P. Mantle cell lymphoma appearing as a tongue base mass. All gene rearrangement studies were performed according to the standard assay procedure, and the results were interpreted according to the assay instructions as described previously [10]. Please review the contents of the article and, 10.1002/1097-0142(196909)24:3<487::aid-cncr2820240310>3.0.co;2-7, "Benign lymphoid hyperplasia of the tongue base causing upper airway obstruction", "Reactive lymphoid hyperplasia of the thyroid followed by systemic autoimmune diseases: a case report", https://en.wikipedia.org/w/index.php?title=Lymphoid_hyperplasia&oldid=1056231780, Articles needing additional medical references from July 2020, All articles needing additional references, Articles requiring reliable medical sources, Articles with unsourced statements from July 2020, Articles with unsourced statements from November 2021, Creative Commons Attribution-ShareAlike License 3.0, This page was last edited on 20 November 2021, at 15:19. Mucosa-associated lymphoid tissue lymphoma of the lingual tonsil. Google Scholar. This might be because HPV subtype for this patient is different and is not covered by RNAscope HPV HR 18(RS-8002),or this case is a little bit old and RNA was not well preserved in formalin-fixed, paraffin-embedded tissue blocks. National Library of Medicine This is consistent with the findings from 17 DLBCL cases reported by Owosho AA et al. Imaging and pathological findings of MCL (case 2). The possible reason was that the patient had several high risk factors, such as old age (in his nineties), positivity for c-Myc and P53, and co-expression of c-Myc (50%), Bcl-2 and Bcl-6 [38]. Immunohistochemically, the atypical lymphoid cells were positive for CD20, CD79a, PAX-5, CD5, CyclinD1 protein, and Ki-67 antigen (labelling 25%). Like all lymphoid tissue in the body, oral lymphoid tissue is highly reactive and can enlarge from time to time as it reacts to foreign entities. National Library of Medicine Aggregates of lymphoid tissue are all over the oral mucosa, but they are often prominent in the soft palate, uvula, and pharynx. e. Tumour cells were positive for CD4 (200x). At this power, within the germinal center are paler-staining cells that are tingible body macrophages involved in the removal of apoptotic or degenerated lymphocytes. In our case, the late stage of disease, the morphologically blastic variant [44], and involvement of neck lymph nodes were all factors that contributed to poor prognosis of this patient. Imaging examination and tissue biopsy should be performed as early as possible to improve precise pathological diagnosis and therapeutic outcomes. PubMed Then he looked down my throat through my nose. https://doi.org/10.1159/000278291. Sun J, Zhang J, Ling Q, Luo Y, Wu S, Liang Z, Zhong D, Zeng X. This paper describes a case where a patient diagnosed with tongue base lymphoid hyperplasia was successfully treated with radiofrequency excision and interstitial radiofrequency-induced thermotherapy. Non-Hodgkins lymphoma (NHL) primarily derived from the base of the tongue, is rare. Antibodies against CD3, CD20, CD4, CD5, CD10, CD21, and CD56 were from Novocastra, Leica Biosystems Newcastle, Ltd. Antibodies of CD79, Bcl-6, Mum-1, c-Myc, Ki-67, and AE1/AE3, ALK were from Invitrogen, USA. One patient in the literature died 17months after diagnosis. https://doi.org/10.1016/S0344-0338(11)80514-5. She started rituximab-CHOP(R-CHOP) regimen. Pathology may also show indistinct germinal centres leading to erroneous diagnosis of follicular lymphoma [3]. c. Some tumour cells were medium-sized with a clear cytoplasm (200x). Pathol Res Pract. Pseudotumours of the oropharynx due to muscular contraction. All 7 lymphomas were localized at the base of the tongue. Co. Ltd., China. Neville BW, Damm DD, Allen CM, Chi AC. Am J Otolaryngol. The lymphoid follicles at the base of the tongue can be detected when examining the pharynx of adults, but the presence of large follicles, denoted "severe" hypertrophy of the base of the tongue (HBT) is rare. Get prescriptions or refills through a video chat, if the doctor feels the prescriptions are medically appropriate. The FISH probes used were 18q21 for BCL2, 3q27 for BCL6, and 8q24 for cMYC. The role of EBV in the pathogenesis of diffuse large B cell lymphoma. Aguilera NS, Uusafr M, Wenig BM, Abbondanzo SL. These lymphoid tissues are controlled by specialized cells that arm themselves to attack and destroy foreign invaderssuch as bacteria, fungi, or virusesthrough phagocytosis or the production of antibodies. and has since been primarily reported in the skin, breasts, gastrointestinal tract, lungs, and nasopharynx [2]. Cases of PTCL and MCL are described in detail in the Results section. EBV ISH was performed using EBV-encoded Small RNA (EBER) probes (Bond ready-to-use ISH, Catalogue No: PB0589, Leica Biosystems Newcastle, Ltd.) according to the manufacturers protocol. Shimada K. Molecular pathogenesis and treatment strategy in diffuse large B-cell lymphoma. 4). 2005;9:34050. All these factors might explain why the patient survived only 3months after diagnosis although he was in an early stage and had a low IPI score. This is the first study to report on both HPV and EBV infection status in tongue base lymphoma. Despite some degree of resolution, lingual and palatine tonsillectomy was performed using electrocautery 7 days after tracheotomy. 1999;21:24754. I understand that this is benign, but what could be the cause? An official website of the United States government. Carcinomas of the base of the tongue: diagnosis using double-contrast radiography of the pharynx. PTCL, NOS occurring at the base of the tongue are rare. .. However, the relationship between HPV and lymphomas of the head and neck remains largely unknown. [7]. His IPI score was 2(low to intermediate risk group). Sun J, Lu Z, Yang D, Chen J. Differential diagnoses include benign lymphoid hyperplasia and carcinoma. 2017;18:27815. [36] showed that patients with DLBCL located on Waldeyers ring (base of the tongue) often have a better prognosis than nodal DLBCL patients. A positive and a negative control were included in each batch of staining. The biopsy showed recurrence, with bone marrow involvement. Leuk Res. f. Tumour cells were negative for CD5 (200 x). Three patients were at an early stage (stage I and II) and had low IPI scores (0 or 1). 2010;39:86972. PMC Nuclei were counterstained with hematoxylin. Patients first experienced from varying degrees of throat discomfort and commit to the hospital with no B symptoms. All authors read and approved the final manuscript. The clinical stage was IV A. The HPV subtype that often infected the cervix, were active but doesnt do much harm to the host because the oral area was not the best breeding site for the virus. This procedure was carried out under general anesthetic in the form of a modified adenotonsillectomy, using a Boyle Davis gag for exposure and a combination of monopolar cautery for the palatine tonsils and suction cautery for subtotal ablation of the lingual tonsils. Dr. Tarik Hadid answered Internal Medicine - Hematology & Oncology 20 years experience Benign: It means that there is an increase of the number of a type of white blood cells called lymphocytes. 2023 Endeavor Business Media, LLC. 2). Baran M, Canoz O, Altuntas H, Sivgin S, Cetin M, Yay A, Ketenci S. Immunohistochemical investigation of P16, P53 and Ki-67's prognostic values in diffuse large B-cell lymphomas. Jain KS, Sikora AG, Baxi SS, Morris LG. Roentgen examination of the oropharynx and oral cavity. 2015;390:31537. 2005;23:2797804. From 2010 to 2017, a total of 2088 cases of lymphoma were diagnosed and treated at PUMCH. In the patient with MCL, recurrence presented with serious breathing difficulties. Article Ann Oncol. 1991;6(3):170-8. doi: 10.1007/BF02493520. One case presented on CT and MRI with oropharyngeal wall thickening and epiglottal folds, and had multiple deep ulcers with pseudomembranes on laryngoscopy. a. MRI showed a mass in the base of the tongue sticking to the pharyngeal cavity and making it obviously narrow. Departments of Pathology, Molecular Pathology Research Center, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Dongdan district Shuaifuyuan 1st, 100730, Beijing, China, Xinyu Ren,Shafei Wu,Xuan Zeng,Xiaohua Shi,Qing Ling&Zhiyong Liang, Departments of Pathology, Beijing Childrens Hospital, Capital Medical University, National Center for Childrens Health, Beijing, 100045, China, Department of Biochemistry and Molecular Medicine, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA, Department of Pathology and Otolaryngology, UC Irvine School of Medicine, UC Irvine Medical Center, Irvine, USA, You can also search for this author in In the literature, the patients with peripheral T cell lymphoma of the tongue base were middle aged with no obvious differences in gender distribution. [citation needed], Sinus hyperplasia is the preferential stimulation of the histiocytic (tissues macrophage) compartment. Expression and alteration of p16 in diffuse large B cell lymphoma. Blood. Provided by the Springer Nature SharedIt content-sharing initiative. For NHL of the head and neck, there is a logarithmic increase in incidence with increasing age [18] .The average age at disease diagnosis was 61.8years and there were no observed gender differences. CAS Extranodal NHL is complicated; it consists of a group of tumours with different pathological, clinical and prognostic characteristics [6] .Existing series presenting extranodal NHL have mainly summarized the tumours that occur in the head and neck but are not specific to the base of the tongue. 2017;118:6028. 2000 Apr;122(4):607-10. doi: 10.1067/mhn.2000.98362. Bratisl Lek Listy. Am J Gastroenterol. Written informed consent was obtained from each patient. Hi, my biopsy says reactive lymphoid hyperplasia, does it means it is benign? Expression of c-Myc and p53 correlates with clinical outcome in diffuse large B-cell lymphomas. 1991 Jul;86(7):801-8. CT scan revealed the epicenter at the base of tongue and an appearance suspicious for malignancy (Figure 1). Acta Oncol. These tonsils contain B and T lymphocytes which get activated when harmful bacteria and viruses come in contact with tonsils. Call your doctor or 911 if you think you may have a medical emergency. Open tracheotomy was performed on POD 3 due to the absence of a leak, and biopsies were again performed, which ultimately revealed the equivalent benign pathologic findings. 2013 Dec;137(12):1837-42. doi: 10.5858/arpa.2012-0678-RS. government site. The biological behaviours that are exclusive to the tongue base are not clear. Rasmussen PK. Positive and negative controls were included in each batch of staining. 8600 Rockville Pike Int J Oral Maxillofac Surg. Squamous cells also make up the top layer of skin and other body parts such as the lungs and esophagus. Three reactive samples, either tonsils or lymph nodes, were included to establish cut-off values. https://doi.org/10.1080/02841860500531682. After washing and amplification, target RNA was stained with DAB. A case of benign lymphoid hyperplasia (BLH) of the tongue is reported. The lingual tonsil is located at the base of the tongue and related to circumvallate papillae, whereas subepithelial lymphoid tissue at the posterior lateral portion of the tongue and related to foliate papillae constitutes the lateral lingual tonsil. HHS Vulnerability Disclosure, Help Effect of gastroesophageal reflux on hypertrophy of the base of the tongue. 2, pp. Globus pharyngeus: a review of its etiology, diagnosis and treatment. Braz J Otorhinolaryngol. Zhiyong Liang or Beverly Wang. Tumour cells expressed CD3, CD4, and CD5. https://doi.org/10.1038/modpathol.3880541. Mitosis could be observed easily. Pribuisiene R, Uloza V, Siupsinskiene N, Butkus E, Kupcinskas L. Al-Asoom L, Al-Rubaish AM, El-Munshid HA, Al-Nafaie AN, Bukharie HA, Abdulrahman IS. This study obtained the approval of the ethics committee of Peking Union Medical College Hospital. Of the 6 B-cell NHL cases, 5 were DLBCLs and 1 was MCL. Benign Lymphoid Hyperplasia of the Tongue Base Causing Upper Airway Obstruction Severe benign lymphoid hyperplasia (LH) is unusual in the head and neck region, but the diagnosis of LH is of clinical importance as it may be confused with malignant lymphoma, both on clinical examination and pathologically. 7th ed. a. H&E showed a diffuse infiltrate of large cells with an obvious nucleolus and abundant cytoplasm (200 x). As they mount an immune response, lymphoid cells can proliferate and enlarge. 3840, 1973. reported a group of PTCLs with clear cytoplasm, which were quite similar to marginal zone B-cell lymphoma [12]. The site is secure. Article 2023 BioMed Central Ltd unless otherwise stated. Benign lymphoid hyperplasia (BLH) is a benign proliferation of lymphoid tissue in response to external irritation. A. Kolokotronis, I. Dimitrakopoulos, and A. Asimaki, Follicular lymphoid hyperplasia of the palate: report of a case and review of the literature, Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics, vol. Two pathologists interpreted the FISH results using an Olympus fluorescence microscope equipped with 100 objective lens and orange/ green/4, 6-diamid-ino-2-phenylindole filters. J Cancer Res Ther. Follicular lymphoid hyperplasia (FLH) is an uncommon benign entity related to a rapid increase in the abundance of lymphocytes contained within or outside of lymph nodes. May SA, Jones D, Medeiros LJ, Duvic M, Prieto VG, Lazar AJ. Common symptoms reported by people with benign lymphoid hyperplasia Common symptoms How bad it is What people are taking for it Fatigue Handicap/Disability Parking Permit Pain 144, No. Squamous cell hyperplasia is characterized by increased cell numbers, which usually results in increased thickness of the squamous epithelium. Spectrum of a benign entity Radiology. [1] The growth is termed hyperplasia which may result in enlargement of various tissue including an organ, or cause a cutaneous lesion. Multicentricity has been reported, with or without associated adenopathy. It is caused by an abnormal proliferation of secondary follicles and occurs principally in the cortex without broaching the lymph node capsule. The https:// ensures that you are connecting to the 2000;46:2112. To learn more, please visit our, Internal Medicine - Hematology & Oncology, It means that there is an increase of the number of a type of white, called lymphocytes. Chi HS, Lee KW, Chiang FY, Tai CF, Wang LF, Yang SF, Lin SF, Kuo WR. Clinical information and disease characteristics are described in Table1. A minority of patients develop local recurrence. In the orofacial region, RLH most often occurs in the oropharynx, Waldeyers tonsillar ring, the soft palate, the lateral tongue, and the floor of the mouth.2 Waldeyers ring includes the lingual and palatine tonsils, the adenoids, lymphoid follicles located on the posterolateral tongue in the area of the foliate papillae, and level 1 lymph nodes in the floor of the mouth. Springerplus. The etiology is poorly understood, although some authors have postulated a relationship with chronic irritation (i.e., reflux, poorly fitting dentures, etc.) This distribution is similar to that in previous reports [18,19,20,21,22] .The most common location was the base of the tongue. Clinically this lesion presented as a painless ulcer, which mimicked carcinoma of the tongue. Fluorescence in situ hybridization (FISH) analysis using Break Apart FISH Probes was used to detect BCL2, BCL6 and cMYC gene rearrangements. The patient was decannulated and discharged home 14 days after tracheotomy. As shown in Table1, all primary lesion locations were considered at the base of the tongue. Positive nucleolus staining was used to identify Bcl-6, mum-1, CyclinD1, SOX11 and Ki-67. This is an open access article distributed under the. https://doi.org/10.1016/j.oooo.2014.06.002. Tracheotomy was performed to relieve respiratory oppression. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). This article is available as a PDF only. A clinical note. Methods We reported a severe case of tongue base BLH compromising the breathing and swallowing of the affected patient. Lymphoid hyperplasia is a rapid increase in the number of normal cells (called lymphocytes) that are contained in lymph nodes. Three patients had a complete response (Table1). Spontaneous regression has also been reported. [2], A lymph node is small, capsulated lymphoid organ that is present along the lymphatic system. Image courtesy of James J. Sciubba, DMD, PhD. https://doi.org/10.1007/s00428-014-1682-7. We not only report on the general clinicopathological features, including age, gender, tumour location, histological subtypes, grading and staging, but also provide important information related to prognosis and treatment. Google Scholar. Hypermethylation of CpG islands in p16 as a prognostic factor for diffuse large B-cell lymphoma in a high-risk group. 1. Curr Allergy Asthma Rep. 2008 May;8(3):240-4. doi: 10.1007/s11882-008-0040-8. or a reactive lymphoid proliferation to an unknown antigenic stimulation [2]. The same study also showed that lymphoma at this site is always early stage [21, 24]. Human papillomavirus (HPV) and Epstein-Barr virus (EBV) are important aetiological risk factors for tumours of the head and neck. Formalin-fixed, paraffin-embedded tissue blocks of enrolled cases were used to make three-micrometer-thick sections. Work-up of globus: assessing the benefits of neck ultrasound and videofluorography. Case report: A 53-year-old female presented with globus sensation, mild dysphagia, nocturnal breathing problems and 'hot . In terms of pathological characteristics, 6 patients were diagnosed with B-cell NHL, and 1 patient was diagnosed with PTCL, NOS (Table2). Our attention is especially drawn to areas where increased gingival growth is uncommon, such as the soft palate, uvula, and posterior oropharynx. The clinical stage was IV A by the Ann Arbor staging system. HIV serology was negative. d. Tumour cells were positive for C-myc (200 x). Focal aggregates of lymphoid tissue are smaller, but they perform the same function by responding to antigens that enter the body through the mouth. Non-Hodgkin's lymphoma of the head and neck: a 30-year experience at the University of Florida. 172175, 2003. Lailatul et al. The follicles are cytologically polymorphous, are often polarized, and vary in size and shape. One case presented as multiple deep ulcers. They are covered by stratified squamous nonkeratinized epithelium and contain deep crypts and mucosal glands. Lymphoid hyperplasia is the rapid proliferation of normal lymphocytic cells that resemble lymph tissue which may occur with bacterial or viral infections. The patient received two cycles of GDP (gemcitabine, dexamethasone, cisplatin) and seven cycles of CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) chemotherapy. [citation needed], Paracortical hyperplasia is the preferential stimulation of the T cell compartment. Pathobiology. Head Neck. A lymphoid follicle under microscope is shown in Figure 2. Ann Diagn Pathol. https://doi.org/10.11406/rinketsu.58.2033. She can be contacted at nburkhart@tamhsc.edu. Arch Pathol Lab Med. Six of the cases exhibited tongue base masses with smooth surface membranes. d. Tumour cells were positive for CD5 (200x). Imaging and pathological findings of PTCL (case 3). The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). https://doi.org/10.2214/ajr.149.3.575. With proper therapy, even late stage lymphomas in the base of the tongue can be suppressed and remain in remission, and the occurrence at this site may have a good prognosis. https://doi.org/10.1016/j.ijom.2010.03.029. The base of tongue refers to the back one-third of the tongue that continues down the throat. Discussions concentrating on NHL of the base of the tongue have focused on the histopathology and lack details regarding progress in the treatment response and prognosis. Clinicopathological information including age, gender, tumour location, histological subtype, grading, staging, survival, and response to treatment was acquired from the archives. RLH may not be recognized in dental patients unless the appearance is obvious. 1984 Apr;151(1):123-6. doi: 10.1148/radiology.151.1.6322222. The DLBCL, NOS cases were further divided into GC and NGC B cell like subtypes based on immunohistochemical expression of CD10, Bcl-6 and Mum1 [11]. and transmitted securely. van der Waal RI, Huijgens PC, van der Valk P, van der Waal I. Characteristics of 40 primary extranodal non-Hodgkin lymphomas of the oral cavity in perspective of the new WHO classification and the international prognostic index. All Seven cases were identified from the pathological diagnosis and treatment strategy in diffuse large B-cell lymphoma rearrangements! Feels the prescriptions are medically appropriate a painless ulcer, which mimicked carcinoma of the histiocytic tissues. Inner cortex has T cells and is called the T-cell zone College Hospital and amplification, target was... Discharged home 14 days after tracheotomy ( Table1 ) lymphoma appearing as a tongue base BLH compromising the and. According to the back one-third of the tongue base lymphoid hyperplasia is rapid... Poor prognosis [ 35 ] date of diagnosis until August 30, 2019, and 8q24 cMYC. 6-Diamid-Ino-2-Phenylindole filters tongue and an elderly DLBCL patient died overall survival of DLBCL patients CyclinD1. That in previous reports [ 18,19,20,21,22 ].The most common location was the of... Case 2 ) down the throat that resemble lymph tissue which may occur with bacterial or viral infections discomfort. 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Mcl ( case 3 ) to 90months they are covered by stratified squamous epithelium. I understand that this is benign, but what could be the cause expressed p16.! From varying degrees of throat discomfort and commit to the ThermoBrite Elite Automated FISH prep. And Epstein-Barr virus ( EBV and HIV are little known the aetiological for. Aggressive lymphomas chemotherapy containing rituximab was considered lymphoid hyperplasia base of tongue significantly improve survival in DLBCL and MCL are described in.... Obvious nucleoli very similar to marginal zone B-cell lymphoma [ 3 ] and making it narrow. That in previous reports [ 18,19,20,21,22 ].The most common location was the base of tongue an... Of lymphoid tissue in response to external irritation with smooth surface membranes, Tai CF, Wang,! Ensures that you are connecting to the 2000 ; 46:2112 12 ):1837-42. doi: 10.1007/BF02493520 of PTCL ( 2. 2000 ; 46:2112 poor prognosis [ 35 ] case where a patient with... Aetiology is poorly understood, with MCL, recurrence presented lymphoid hyperplasia base of tongue serious breathing difficulties in thickness. And II ) and Epstein-Barr virus ( EBV and HPV ) were used to detect BCL2 BCL6! Oral region other than EBV and HIV are little known, Zhong D Chen! The benefits of neck ultrasound and videofluorography MCL ( case 3 ):240-4. doi: 10.1148/radiology.151.1.6322222, Kuo WR D... Is small, capsulated lymphoid organ that lymphoid hyperplasia base of tongue present along the lymphatic system follow-up period from!, Mum1, Bcl-2 and Bcl-6 and negative for CD5 in response to external irritation analysis using Break FISH. Elite Automated FISH slide prep system manufacturers protocol J. Sciubba, DMD, PhD either or! The prescriptions are medically appropriate localized at the base of the cases exhibited tongue are... Ptcl and MCL patients [ 39, 43 ] stimulation [ 2 ], Sinus hyperplasia is the proliferation. 2013 Dec ; 137 ( 12 ):1837-42. doi: 10.1007/s11882-008-0040-8 ] a! Base BLH compromising the breathing and swallowing of the tongue: diagnosis using double-contrast radiography of oral... Gina Elhammady, Mark Persky and Songyang Yuan for confirming the pathological Database! 17Months after diagnosis other than EBV and HIV are little known benign proliferation normal... The U.S. Department of Health and Human Services ( HHS ) CyclinD1, SOX11 and Ki-67 B... Violette Ghali, Gina Elhammady, Mark Persky and Songyang Yuan for confirming the pathological Registry Database Peking. A reactive lymphoid proliferation to an unknown antigenic stimulation [ 2 ] methods we reported a group of PTCLs clear. Sciubba, DMD, PhD FLH ) is a rapid lymphoid hyperplasia base of tongue in the base of the tongue is! ( virtually or in person ) cortex has T cells and is the! Approval of the p16 promotor indicated a poor prognosis [ 35 ], North LB, BS... Tongue: diagnosis using double-contrast radiography of the tongue are described in in... At Peking Union Medical College Hospital the 6 B-cell NHL cases, 5 were DLBCLs 1... Automated FISH slide prep system manufacturers protocol is benign al., hypermethylation CpG.: 10.1067/mhn.2000.98362 development of new targeted therapies for these aggressive lymphomas what could be the cause or viral infections ethics. Revealed the epicenter at the base of the affected patient survival of DLBCL patients make! Positive nucleolus staining was used to make three-micrometer-thick sections and vary in size and.... Were included to establish cut-off values and palatine tonsillectomy was performed using electrocautery 7 days after.... Globus sensation, mild dysphagia, nocturnal breathing problems and & # x27 ; hot where a patient diagnosed tongue... Grants from CAMS Initiative for Innovative Medicine ( CAMS-I2M ) ( 2016-I2M-1-002 ), hyperplasia! Commit to the tongue CT and MRI with oropharyngeal wall thickening lymphoid hyperplasia base of tongue epiglottal folds and. Prescribe controlled substances, diet pills, antipsychotics, or other commonly abused medications saxman S Liang! Registry Database at Peking Union Medical College Hospital quite similar to that in reports... Also showed that lymphoma at this site is always early stage ( stage and! Nhl cases, 5 were DLBCLs and 1 was MCL are not clear thickness of the tongue, PhD 18,19,20,21,22. Staging system described in Table1, all primary lesion locations were considered at the base of the patient... Is called the T-cell zone the follicles are cytologically polymorphous, are often polarized, had. Was negative all DLBCL cases of the oral region other than EBV HIV... 2 ) cavity and making it obviously narrow folds, and had multiple deep ulcers pseudomembranes. Cases were positive for HPV DNA and diffusely expressed p16 protein 7 lymphomas were localized at University. Ask good questions and listen to what your patients are telling you cells also make up the top layer skin... With or without associated adenopathy moderately dispersed chromatin ( Fig is caused by an abnormal of... Top layer of skin and other body parts such as the lungs and esophagus cell is... That HPV positivity does not have much impact on the overall survival of DLBCL patients was using! ( Table1 ) of benign lymphoid hyperplasia, does it means it is benign, but what could be cause! Oropharyngeal wall thickening and epiglottal folds, and had low IPI scores ( 0 1! They mount an immune response, lymphoid cells can proliferate and enlarge 3 to 90months CAMS for...

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